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KMID : 0369820050350020107
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Jorunal of Korean Pharmaceutical Sciences
2005 Volume.35 No. 2 p.107 ~ p.110
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Physicochemical Characterization of Clotrimazole-Loaded Solid Suppository Using Poloxamer and Propylene Glycol
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현경희/Xuan JJ
오유경/김정애/공경환/김지현/양준호/배명수/김호동/이종달/장현욱/용철순/Oh YK/Kim JA/Gong KH/Kim JH/Yang JH/Bae MS/Kim HD/Rhee JD/Chang HW/Yon CS
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Abstract
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To develop a clotrimazole-loaded solid suppository with poloxamer and propylene glycol, the melting points of various formulations composed of poloxamer 188 (P 188) and propylene glycol were investigated. The dissolution study of clotrimazole delivered by the suppository composed of P 188 and propylene glycol was performed. The mixtures composed of P 188 and propylene glycol were homogeneous. Propylene glycol affected the melting points of poloxamer mixtures. In particular, the mixture [P 188/propylene glycol (70/30%)] with the melting point of about 32°C was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, propylene glycol affected greatly the dissolution rates of clotrimazole from the suppository. Dissolution mechanism analysis showed the dissolution of clotrimazole was proportional to the time. Our results indicated that the solid suppository with P 188 and propylene glycol would be a candidate of rectal dosage form for clotrimazole.
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KEYWORD
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clotrimazole, propylene glycol, poloxamer 188, suppository, melting point
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